{"acc":"Q9H0R3","reviewed":true,"gene":"TMEM222","proteome":"UP000005640","name":"Transmembrane protein 222","length":208,"organism":"Homo sapiens (Human)","ncbi_taxon_id":9606,"taxonomy":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"],"sequence":"MAEAEGSSLLLLPPPPPPPRMAEVEAPTAAETDMKQYQGSGGVAMDVERSRFPYCVVWTPIPVLTWFFPIIGHMGICTSTGVIRDFAGPYFVSEDNMAFGKPAKYWKLDPAQVYASGPNAWDTAVHDASEEYKHRMHNLCCDNCHSHVALALNLMRYNNSTNWNMVTLCFFCLLYGKYVSVGAFVKTWLPFILLLGIILTVSLVFNLR","localization":["Membrane; Multi-pass membrane protein","Cell projection, dendrite"],"uniref100":"UniRef100_Q9H0R3","uniref90":"UniRef90_Q9H0R3","uniref50":"UniRef50_Q9H0R3","uniparc":"UPI0000DB3EE6","homology-domain-merge":{"regions":[[46,176]],"content_fraction":0.63,"content_count":131},"homology-domain-pfam":{"regions":[[46,176]],"content_fraction":0.63,"content_count":131,"regions_ids":["PF05608"],"regions_names":["TMEM222/RTE1"]},"level":1,"prediction-disorder-alphafold":{"scores":[0.917,0.919,0.913,0.907,0.903,0.896,0.901,0.904,0.908,0.904,0.907,0.907,0.908,0.899,0.895,0.89,0.892,0.891,0.889,0.888,0.885,0.876,0.87,0.858,0.841,0.845,0.821,0.828,0.833,0.82,0.807,0.789,0.754,0.728,0.713,0.702,0.695,0.66,0.641,0.609,0.577,0.549,0.515,0.482,0.446,0.42,0.391,0.366,0.343,0.347,0.334,0.336,0.296,0.281,0.281,0.283,0.268,0.282,0.285,0.271,0.243,0.212,0.209,0.197,0.197,0.201,0.199,0.225,0.225,0.232,0.23,0.235,0.227,0.222,0.206,0.19,0.199,0.223,0.223,0.204,0.182,0.201,0.193,0.211,0.212,0.227,0.245,0.263,0.291,0.294,0.292,0.285,0.264,0.267,0.277,0.278,0.288,0.305,0.335,0.337,0.339,0.339,0.325,0.338,0.361,0.394,0.404,0.398,0.366,0.373,0.376,0.36,0.342,0.333,0.348,0.345,0.344,0.353,0.365,0.35,0.362,0.377,0.374,0.364,0.363,0.371,0.378,0.396,0.389,0.37,0.341,0.311,0.31,0.313,0.303,0.284,0.284,0.291,0.272,0.254,0.263,0.28,0.267,0.268,0.269,0.279,0.271,0.268,0.269,0.291,0.278,0.267,0.252,0.244,0.248,0.243,0.25,0.271,0.28,0.281,0.297,0.327,0.344,0.349,0.369,0.371,0.363,0.382,0.399,0.42,0.401,0.397,0.405,0.414,0.383,0.391,0.393,0.389,0.38,0.393,0.417,0.42,0.414,0.415,0.438,0.442,0.437,0.437,0.45,0.447,0.462,0.479,0.488,0.489,0.498,0.534,0.547,0.562,0.559,0.585,0.6,0.596,0.605,0.618,0.62,0.616,0.628,0.625],"content_fraction":0.236,"content_count":49,"regions":[[1,40],[200,208]]},"prediction-disorder-dis465":{"regions":[[1,8],[24,26],[37,41],[207,208]],"content_count":18,"content_fraction":0.087},"prediction-disorder-disHL":{"regions":[[1,19],[201,201],[207,208]],"content_count":22,"content_fraction":0.106},"prediction-disorder-espD":{"regions":[[2,9]],"content_count":8,"content_fraction":0.038},"prediction-disorder-espN":{"regions":[[1,31],[36,51],[87,87]],"content_count":48,"content_fraction":0.231},"prediction-disorder-espX":{"regions":[[1,34]],"content_count":34,"content_fraction":0.163},"prediction-disorder-glo":{"regions":[[5,7],[11,23],[117,117],[199,199],[201,201],[205,205]],"content_count":20,"content_fraction":0.096},"prediction-disorder-iupl":{"regions":[[8,10],[12,18],[20,33],[35,35],[37,40]],"content_count":29,"content_fraction":0.139},"prediction-disorder-iups":{"regions":[[1,37]],"content_count":37,"content_fraction":0.178},"prediction-disorder-mobidb_lite":{"regions":[[1,26]],"content_count":26,"content_fraction":0.125,"scores":[0.625,0.75,0.75,0.75,0.875,0.875,0.875,0.875,0.75,0.625,0.625,0.75,0.75,0.75,0.75,0.75,0.75,0.75,0.625,0.625,0.625,0.625,0.625,0.625,0.625,0.625,0.5,0.5,0.5,0.5,0.5,0.375,0.375,0.25,0.25,0.25,0.5,0.375,0.375,0.375,0.25,0.125,0.125,0.125,0.125,0.125,0.125,0.125,0.125,0.125,0.125,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.125,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.125,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.125,0,0.25,0,0,0,0.125,0,0.25,0.25]},"prediction-disorder-priority":{"regions":[[1,40],[200,208]],"content_fraction":0.236,"content_count":49},"prediction-disorder-th_50":{"regions":[[1,31],[37,37]],"content_count":32,"content_fraction":0.154},"prediction-lip-alphafold":{"scores":[0.758,0.746,0.747,0.737,0.772,0.735,0.777,0.766,0.751,0.773,0.768,0.77,0.771,0.77,0.773,0.776,0.789,0.801,0.799,0.79,0.763,0.775,0.745,0.761,0.744,0.756,0.743,0.743,0.781,0.781,0.769,0.753,0.771,0.761,0.766,0.75,0.757,0.74,0.737,0.768,0.577,0.549,0.515,0.482,0.446,0.42,0.391,0.366,0.343,0.347,0.334,0.336,0.296,0.281,0.281,0.283,0.268,0.282,0.285,0.271,0.243,0.212,0.209,0.197,0.197,0.201,0.199,0.225,0.225,0.232,0.23,0.235,0.227,0.222,0.206,0.19,0.199,0.223,0.223,0.204,0.182,0.201,0.193,0.211,0.212,0.227,0.245,0.263,0.291,0.294,0.292,0.285,0.264,0.267,0.277,0.278,0.288,0.305,0.335,0.337,0.339,0.339,0.325,0.338,0.361,0.394,0.404,0.398,0.366,0.373,0.376,0.36,0.342,0.333,0.348,0.345,0.344,0.353,0.365,0.35,0.362,0.377,0.374,0.364,0.363,0.371,0.378,0.396,0.389,0.37,0.341,0.311,0.31,0.313,0.303,0.284,0.284,0.291,0.272,0.254,0.263,0.28,0.267,0.268,0.269,0.279,0.271,0.268,0.269,0.291,0.278,0.267,0.252,0.244,0.248,0.243,0.25,0.271,0.28,0.281,0.297,0.327,0.344,0.349,0.369,0.371,0.363,0.382,0.399,0.42,0.401,0.397,0.405,0.414,0.383,0.391,0.393,0.389,0.38,0.393,0.417,0.42,0.414,0.415,0.438,0.442,0.437,0.437,0.45,0.447,0.462,0.479,0.488,0.489,0.498,0.534,0.547,0.562,0.559,0.985,0.981,0.978,0.98,0.981,0.966,0.953,0.933,0.863],"content_fraction":0.087,"content_count":18,"regions":[[16,20],[200,208]]},"prediction-lip-anchor":{"regions":[[6,9]],"content_count":4,"content_fraction":0.019},"prediction-lip-priority":{"regions":[[6,9],[16,20],[200,208]],"content_fraction":0.087,"content_count":18},"prediction-low_complexity-seg":{"regions":[[9,19]],"content_count":11,"content_fraction":0.053},"prediction-plddt-alphafold":{"scores":[0.423,0.394,0.395,0.373,0.456,0.368,0.469,0.44,0.406,0.457,0.446,0.452,0.453,0.452,0.458,0.465,0.496,0.525,0.52,0.5,0.435,0.464,0.39,0.429,0.39,0.419,0.386,0.388,0.479,0.478,0.449,0.41,0.452,0.429,0.441,0.403,0.42,0.379,0.373,0.445,0.485,0.564,0.675,0.783,0.877,0.909,0.917,0.921,0.934,0.957,0.973,0.974,0.978,0.976,0.982,0.984,0.981,0.982,0.97,0.969,0.955,0.941,0.943,0.939,0.95,0.959,0.962,0.95,0.94,0.933,0.933,0.954,0.97,0.977,0.982,0.987,0.984,0.98,0.97,0.96,0.97,0.979,0.984,0.985,0.98,0.965,0.941,0.918,0.908,0.935,0.948,0.968,0.966,0.976,0.952,0.948,0.962,0.947,0.951,0.95,0.967,0.974,0.971,0.974,0.977,0.977,0.974,0.977,0.966,0.953,0.961,0.972,0.98,0.971,0.956,0.909,0.897,0.886,0.936,0.975,0.983,0.982,0.983,0.986,0.986,0.982,0.982,0.983,0.98,0.977,0.97,0.958,0.945,0.922,0.92,0.878,0.814,0.813,0.769,0.779,0.772,0.867,0.929,0.959,0.969,0.972,0.979,0.984,0.983,0.983,0.986,0.986,0.986,0.984,0.982,0.982,0.983,0.971,0.977,0.979,0.975,0.977,0.982,0.967,0.949,0.943,0.96,0.967,0.948,0.963,0.968,0.951,0.94,0.96,0.973,0.969,0.972,0.976,0.966,0.964,0.973,0.966,0.967,0.973,0.97,0.952,0.964,0.975,0.971,0.972,0.974,0.978,0.977,0.965,0.964,0.974,0.971,0.957,0.959,0.965,0.956,0.948,0.952,0.955,0.918,0.888,0.841,0.673],"content_fraction":0.788,"content_count":164,"regions":[[44,207]]},"prediction-transmembrane-uniprot":{"regions":[[56,76],[165,185],[187,207]],"content_count":63,"content_fraction":0.30288461538461536}}