{"acc":"Q03135","reviewed":true,"gene":"CAV1","proteome":"UP000005640","name":"Caveolin-1","length":178,"organism":"Homo sapiens (Human)","ncbi_taxon_id":9606,"taxonomy":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"],"sequence":"MSGGKYVDSEGHLYTVPIREQGNIYKPNNKAMADELSEKQVYDAHTKEIDLVNRDPKHLNDDVVKIDFEDVIAEPEGTHSFDGIWKASFTTFTVTKYWFYRLLSALFGIPMALIWGIYFAILSFLHIWAVVPCIKSFLIEIQCISRVYSIYVHTVCDPLFEAVGKIFSNVRINLQKEI","localization":["Golgi apparatus membrane; Peripheral membrane protein","Cell membrane; Peripheral membrane protein","Membrane, caveola; Peripheral membrane protein","Membrane raft","Golgi apparatus, trans-Golgi network"],"uniref100":"UniRef100_Q03135","uniref90":"UniRef90_Q03135","uniref50":"UniRef50_Q03135","uniparc":"UPI00001270ED","ptms":{"names":["N-acetylserine","Phosphoserine","N6-acetyllysine; alternate","Phosphotyrosine","Phosphoserine","Phosphotyrosine; by ABL1","Phosphotyrosine","Phosphoserine"],"positions":[[2,2],[2,2],[5,5],[6,6],[9,9],[14,14],[25,25],[37,37]]},"processing":{"positions":[[2,94],[82,94],[131,142],[149,160],[167,178]],"names":["Required for homooligomerization","Interaction with CAVIN3","Interacts with SPRY1, SPRY2, SPRY3 and SPRY4","Interacts with SPRY1, SPRY2, and SPRY4","Interacts with SPRY1, SPRY2, SPRY3 and SPRY4"]},"homology-domain-pfam":{"regions":[[43,174]],"content_fraction":0.742,"content_count":132,"regions_ids":["PF01146"],"regions_names":["Caveolin"]},"homology-domain-merge":{"regions":[[43,174]],"content_fraction":0.742,"content_count":132},"prediction-disorder-disHL":{"regions":[[1,25],[48,61],[74,85],[173,178]],"content_count":57,"content_fraction":0.32},"prediction-disorder-dis465":{"regions":[[1,6],[8,8],[176,178]],"content_count":10,"content_fraction":0.056},"prediction-disorder-espN":{"regions":[[1,11]],"content_count":11,"content_fraction":0.062},"prediction-disorder-espX":{"regions":[[1,9],[175,178]],"content_count":13,"content_fraction":0.073},"prediction-disorder-glo":{"regions":[[1,3],[7,8],[172,172]],"content_count":6,"content_fraction":0.034},"prediction-disorder-iups":{"regions":[[1,8],[29,31],[36,37],[177,178]],"content_count":15,"content_fraction":0.084},"prediction-disorder-th_50":{"regions":[[1,8],[177,178]],"content_count":10,"content_fraction":0.056},"derived-lip-flipper-7sc0_A":{"source_id":"7sc0_A","regions":[[49,177]],"content_fraction":0.725,"content_count":129},"derived-lip-flipper-7sc0_B":{"source_id":"7sc0_B","regions":[[49,85],[91,177]],"content_fraction":0.697,"content_count":124},"derived-lip-flipper-7sc0_C":{"source_id":"7sc0_C","regions":[[49,177]],"content_fraction":0.725,"content_count":129},"derived-lip-flipper-7sc0_D":{"source_id":"7sc0_D","regions":[[49,85],[91,177]],"content_fraction":0.697,"content_count":124},"derived-lip-flipper-7sc0_E":{"source_id":"7sc0_E","regions":[[49,177]],"content_fraction":0.725,"content_count":129},"derived-lip-flipper-7sc0_F":{"source_id":"7sc0_F","regions":[[49,177]],"content_fraction":0.725,"content_count":129},"derived-lip-flipper-7sc0_G":{"source_id":"7sc0_G","regions":[[49,177]],"content_fraction":0.725,"content_count":129},"derived-lip-flipper-7sc0_H":{"source_id":"7sc0_H","regions":[[49,177]],"content_fraction":0.725,"content_count":129},"derived-lip-flipper-7sc0_I":{"source_id":"7sc0_I","regions":[[49,177]],"content_fraction":0.725,"content_count":129},"derived-lip-flipper-7sc0_J":{"source_id":"7sc0_J","regions":[[49,177]],"content_fraction":0.725,"content_count":129},"derived-lip-flipper-7sc0_K":{"source_id":"7sc0_K","regions":[[49,177]],"content_fraction":0.725,"content_count":129},"derived-lip-merge":{"regions":[[49,177]],"content_fraction":0.725,"content_count":129},"derived-lip-th_90":{"regions":[[49,85],[91,177]],"content_fraction":0.697,"content_count":124},"derived-missing_residues-mobi-7sc0_A":{"source_id":"7sc0_A","regions":[[1,48],[178,178]],"content_fraction":0.275,"content_count":49},"derived-missing_residues-mobi-7sc0_B":{"source_id":"7sc0_B","regions":[[1,48],[178,178]],"content_fraction":0.275,"content_count":49},"derived-missing_residues-mobi-7sc0_C":{"source_id":"7sc0_C","regions":[[1,48],[178,178]],"content_fraction":0.275,"content_count":49},"derived-missing_residues-mobi-7sc0_D":{"source_id":"7sc0_D","regions":[[1,48],[178,178]],"content_fraction":0.275,"content_count":49},"derived-missing_residues-mobi-7sc0_E":{"source_id":"7sc0_E","regions":[[1,48],[178,178]],"content_fraction":0.275,"content_count":49},"derived-missing_residues-mobi-7sc0_F":{"source_id":"7sc0_F","regions":[[1,48],[178,178]],"content_fraction":0.275,"content_count":49},"derived-missing_residues-mobi-7sc0_G":{"source_id":"7sc0_G","regions":[[1,48],[178,178]],"content_fraction":0.275,"content_count":49},"derived-missing_residues-mobi-7sc0_H":{"source_id":"7sc0_H","regions":[[1,48],[178,178]],"content_fraction":0.275,"content_count":49},"derived-missing_residues-mobi-7sc0_I":{"source_id":"7sc0_I","regions":[[1,48],[178,178]],"content_fraction":0.275,"content_count":49},"derived-missing_residues-mobi-7sc0_J":{"source_id":"7sc0_J","regions":[[1,48],[178,178]],"content_fraction":0.275,"content_count":49},"derived-missing_residues-mobi-7sc0_K":{"source_id":"7sc0_K","regions":[[1,48],[178,178]],"content_fraction":0.275,"content_count":49},"derived-missing_residues-th_90":{"regions":[[1,48]],"content_fraction":0.27,"content_count":48},"derived-observed-mobi-7sc0_A":{"source_id":"7sc0_A","regions":[[49,177]],"content_fraction":0.725,"content_count":129},"derived-observed-mobi-7sc0_B":{"source_id":"7sc0_B","regions":[[49,177]],"content_fraction":0.725,"content_count":129},"derived-observed-mobi-7sc0_C":{"source_id":"7sc0_C","regions":[[49,177]],"content_fraction":0.725,"content_count":129},"derived-observed-mobi-7sc0_D":{"source_id":"7sc0_D","regions":[[49,177]],"content_fraction":0.725,"content_count":129},"derived-observed-mobi-7sc0_E":{"source_id":"7sc0_E","regions":[[49,177]],"content_fraction":0.725,"content_count":129},"derived-observed-mobi-7sc0_F":{"source_id":"7sc0_F","regions":[[49,177]],"content_fraction":0.725,"content_count":129},"derived-observed-mobi-7sc0_G":{"source_id":"7sc0_G","regions":[[49,177]],"content_fraction":0.725,"content_count":129},"derived-observed-mobi-7sc0_H":{"source_id":"7sc0_H","regions":[[49,177]],"content_fraction":0.725,"content_count":129},"derived-observed-mobi-7sc0_I":{"source_id":"7sc0_I","regions":[[49,177]],"content_fraction":0.725,"content_count":129},"derived-observed-mobi-7sc0_J":{"source_id":"7sc0_J","regions":[[49,177]],"content_fraction":0.725,"content_count":129},"derived-observed-mobi-7sc0_K":{"source_id":"7sc0_K","regions":[[49,177]],"content_fraction":0.725,"content_count":129},"derived-observed-th_90":{"regions":[[49,177]],"content_fraction":0.725,"content_count":129},"level":1,"prediction-disorder-alphafold":{"scores":[0.672,0.668,0.675,0.665,0.671,0.66,0.685,0.694,0.704,0.71,0.73,0.747,0.746,0.741,0.733,0.742,0.764,0.767,0.756,0.756,0.765,0.745,0.742,0.741,0.735,0.732,0.739,0.735,0.752,0.751,0.739,0.731,0.736,0.726,0.717,0.723,0.718,0.699,0.696,0.703,0.689,0.683,0.663,0.668,0.67,0.672,0.684,0.682,0.672,0.693,0.699,0.694,0.693,0.684,0.672,0.657,0.646,0.633,0.624,0.622,0.606,0.582,0.585,0.591,0.587,0.6,0.597,0.604,0.615,0.617,0.62,0.609,0.599,0.613,0.594,0.578,0.569,0.565,0.567,0.557,0.571,0.572,0.564,0.563,0.565,0.568,0.585,0.588,0.57,0.562,0.556,0.542,0.555,0.547,0.538,0.527,0.535,0.541,0.534,0.539,0.551,0.558,0.561,0.558,0.571,0.576,0.58,0.585,0.587,0.581,0.572,0.57,0.565,0.566,0.563,0.572,0.573,0.562,0.548,0.544,0.548,0.539,0.546,0.547,0.55,0.549,0.553,0.553,0.555,0.552,0.553,0.554,0.55,0.554,0.563,0.571,0.562,0.568,0.572,0.558,0.55,0.56,0.557,0.554,0.555,0.555,0.56,0.565,0.565,0.558,0.551,0.54,0.538,0.543,0.55,0.553,0.561,0.57,0.577,0.582,0.591,0.615,0.625,0.637,0.664,0.681,0.693,0.716,0.742,0.762,0.78,0.786,0.79,0.794,0.808,0.814,0.825,0.831],"content_fraction":0.551,"content_count":98,"regions":[[1,75],[160,178]]},"prediction-lip-alphafold":{"scores":[0.759,0.785,0.804,0.779,0.806,0.819,0.826,0.856,0.848,0.852,0.831,0.813,0.806,0.808,0.825,0.808,0.815,0.803,0.799,0.81,0.769,0.773,0.757,0.807,0.8,0.777,0.764,0.801,0.819,0.823,0.83,0.817,0.819,0.829,0.826,0.826,0.828,0.811,0.799,0.808,0.804,0.793,0.813,0.833,0.823,0.823,0.838,0.844,0.883,0.904,0.904,0.906,0.92,0.922,0.923,0.928,0.932,0.922,0.925,0.924,0.911,0.89,0.863,0.862,0.887,0.897,0.929,0.944,0.936,0.934,0.937,0.935,0.925,0.925,0.915,0.578,0.569,0.565,0.567,0.557,0.571,0.572,0.564,0.563,0.565,0.568,0.964,0.963,0.57,0.562,0.556,0.542,0.555,0.547,0.538,0.527,0.535,0.541,0.534,0.539,0.551,0.558,0.561,0.558,0.571,0.576,0.58,0.97,0.96,0.581,0.572,0.57,0.565,0.566,0.563,0.572,0.573,0.562,0.548,0.544,0.548,0.539,0.546,0.547,0.55,0.549,0.553,0.553,0.555,0.552,0.553,0.554,0.55,0.554,0.563,0.571,0.562,0.568,0.572,0.558,0.55,0.56,0.557,0.554,0.555,0.555,0.56,0.565,0.565,0.558,0.551,0.54,0.538,0.543,0.55,0.553,0.561,0.57,0.577,0.949,0.947,0.947,0.949,0.952,0.942,0.927,0.922,0.91,0.892,0.905,0.886,0.912,0.906,0.925,0.899,0.9,0.901,0.87],"content_fraction":0.522,"content_count":93,"regions":[[2,20],[28,75],[160,178]]},"prediction-plddt-alphafold":{"scores":[0.425,0.488,0.533,0.474,0.537,0.568,0.584,0.656,0.636,0.647,0.598,0.553,0.538,0.541,0.581,0.542,0.559,0.53,0.519,0.546,0.449,0.459,0.421,0.539,0.522,0.467,0.437,0.525,0.569,0.577,0.593,0.564,0.568,0.593,0.586,0.585,0.59,0.549,0.521,0.541,0.531,0.507,0.555,0.601,0.579,0.579,0.614,0.628,0.721,0.77,0.772,0.776,0.809,0.814,0.815,0.829,0.837,0.814,0.822,0.818,0.787,0.738,0.673,0.671,0.73,0.754,0.831,0.866,0.847,0.843,0.849,0.846,0.822,0.821,0.797,0.753,0.72,0.732,0.802,0.799,0.844,0.875,0.876,0.895,0.889,0.903,0.915,0.912,0.908,0.903,0.922,0.907,0.897,0.918,0.92,0.902,0.898,0.925,0.926,0.917,0.911,0.935,0.93,0.926,0.922,0.933,0.953,0.928,0.905,0.947,0.941,0.928,0.941,0.96,0.954,0.944,0.957,0.963,0.943,0.952,0.959,0.945,0.94,0.952,0.952,0.934,0.947,0.943,0.919,0.927,0.928,0.931,0.915,0.937,0.931,0.91,0.925,0.919,0.912,0.904,0.909,0.903,0.864,0.909,0.911,0.904,0.902,0.909,0.904,0.905,0.904,0.903,0.892,0.872,0.854,0.862,0.848,0.874,0.862,0.877,0.873,0.873,0.879,0.887,0.86,0.826,0.815,0.786,0.742,0.773,0.729,0.791,0.775,0.821,0.758,0.761,0.764,0.691],"content_fraction":0.713,"content_count":127,"regions":[[49,62],[65,177]]},"derived-lip-priority":{"regions":[[49,177]],"content_fraction":0.725,"content_count":129},"derived-missing_residues-priority":{"regions":[[1,48]],"content_fraction":0.27,"content_count":48},"derived-observed-priority":{"regions":[[49,177]],"content_fraction":0.725,"content_count":129},"prediction-disorder-priority":{"regions":[[178,178]],"content_fraction":0.006,"content_count":1},"prediction-lip-priority":{"regions":[[2,20],[28,48],[178,178]],"content_fraction":0.23,"content_count":41},"derived-binding_mode_disorder_to_disorder-mobi":{"regions":[[1,48]],"content_fraction":0.27,"content_count":48},"derived-binding_mode_disorder_to_disorder-priority":{"regions":[[1,48]],"content_fraction":0.27,"content_count":48}}