{"acc":"P17290","reviewed":true,"gene":"TPH1","proteome":"UP000001811","name":"Tryptophan 5-hydroxylase 1","length":444,"organism":"Oryctolagus cuniculus (Rabbit)","ncbi_taxon_id":9986,"taxonomy":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Glires","Lagomorpha","Leporidae","Oryctolagus"],"sequence":"MIEDNKENKDHSLERGRATLIFSLKNEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEFEIFVDCDTNREQLNDIFHLLKSHTNVLSVTPPDNFTMKEEGMESVPWFPKKISDLDHCANRVLMYGSELDADHPGFKDNVYRKRRKYFADLAMSYKYGDPIPKVEFTEEEIKTWGTVFRELNKLYPTHACREYLKNLPLLSKYCGYREDNIPQLEDISNFLKERTGFSIRPVAGYLSPRDFLSGLAFRVFHCTQYVRHSSDPFYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASEEAVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELKHVLSGHAKVKPFDPKITYKQECLITTFQDVYFVSESFEDAKEKMREFTKTIKRPFGVKYNPYTRSIQILKDAKSITNAMNELRHDLDVVSDALGKVSRQLSV","uniref100":"UniRef100_P17290","uniref90":"UniRef90_P17752","uniref50":"UniRef50_P17752","uniparc":"UPI00001372B6","ptms":{"names":["Phosphoserine; by PKA"],"positions":[[58,58]]},"homology-domain-gene3d":{"regions":[[4,439]],"content_fraction":0.982,"content_count":436,"regions_ids":["1.10.800.10"],"regions_names":["Aromatic amino acid hydroxylase superfamily"]},"homology-domain-merge":{"regions":[[4,439]],"content_fraction":0.982,"content_count":436},"homology-domain-pfam":{"regions":[[106,435],[19,72]],"content_fraction":0.865,"content_count":384,"regions_ids":["PF00351","PF01842"],"regions_names":["Aromatic amino acid hydroxylase, C-terminal","ACT domain"]},"level":1,"prediction-disorder-alphafold":{"scores":[0.908,0.909,0.901,0.871,0.857,0.82,0.789,0.752,0.724,0.684,0.647,0.613,0.6,0.594,0.574,0.576,0.553,0.516,0.494,0.481,0.461,0.424,0.4,0.384,0.352,0.327,0.329,0.333,0.337,0.351,0.355,0.374,0.386,0.398,0.414,0.431,0.436,0.432,0.411,0.415,0.376,0.399,0.425,0.434,0.445,0.449,0.451,0.459,0.447,0.446,0.451,0.422,0.396,0.384,0.361,0.358,0.335,0.346,0.351,0.341,0.325,0.335,0.33,0.317,0.304,0.331,0.309,0.28,0.279,0.269,0.27,0.27,0.27,0.271,0.279,0.289,0.302,0.316,0.332,0.321,0.334,0.348,0.342,0.327,0.358,0.397,0.4,0.423,0.457,0.452,0.46,0.471,0.474,0.454,0.45,0.43,0.428,0.422,0.438,0.431,0.43,0.425,0.41,0.402,0.43,0.417,0.4,0.396,0.4,0.368,0.341,0.338,0.306,0.278,0.292,0.276,0.254,0.267,0.294,0.303,0.303,0.316,0.302,0.292,0.325,0.324,0.346,0.372,0.369,0.353,0.385,0.392,0.38,0.383,0.393,0.381,0.365,0.377,0.376,0.359,0.352,0.371,0.359,0.346,0.33,0.358,0.366,0.394,0.381,0.358,0.373,0.345,0.353,0.354,0.356,0.361,0.375,0.378,0.369,0.385,0.386,0.384,0.366,0.367,0.366,0.357,0.349,0.355,0.339,0.336,0.33,0.314,0.287,0.309,0.321,0.299,0.297,0.262,0.28,0.27,0.234,0.227,0.244,0.233,0.204,0.225,0.237,0.236,0.241,0.269,0.29,0.277,0.273,0.273,0.277,0.27,0.29,0.303,0.28,0.256,0.256,0.257,0.265,0.256,0.252,0.252,0.253,0.235,0.235,0.248,0.259,0.259,0.262,0.266,0.237,0.218,0.216,0.212,0.213,0.198,0.183,0.159,0.168,0.169,0.176,0.181,0.183,0.177,0.169,0.169,0.17,0.154,0.151,0.151,0.137,0.112,0.102,0.1,0.083,0.083,0.078,0.078,0.078,0.078,0.077,0.079,0.09,0.094,0.108,0.107,0.114,0.13,0.138,0.144,0.145,0.154,0.154,0.154,0.154,0.158,0.15,0.148,0.148,0.147,0.148,0.148,0.147,0.146,0.146,0.144,0.144,0.154,0.137,0.122,0.115,0.111,0.093,0.084,0.073,0.08,0.07,0.07,0.075,0.076,0.071,0.069,0.071,0.071,0.089,0.103,0.129,0.133,0.133,0.155,0.165,0.16,0.145,0.138,0.138,0.14,0.133,0.133,0.133,0.131,0.128,0.132,0.132,0.127,0.127,0.145,0.151,0.189,0.217,0.223,0.224,0.205,0.202,0.201,0.18,0.17,0.173,0.167,0.165,0.167,0.173,0.169,0.19,0.193,0.193,0.21,0.218,0.219,0.231,0.246,0.263,0.291,0.257,0.257,0.249,0.253,0.275,0.276,0.289,0.289,0.312,0.332,0.332,0.344,0.371,0.372,0.397,0.388,0.392,0.428,0.438,0.448,0.465,0.455,0.463,0.43,0.396,0.39,0.368,0.354,0.356,0.343,0.345,0.347,0.355,0.331,0.309,0.331,0.331,0.302,0.306,0.299,0.288,0.286,0.278,0.27,0.252,0.273,0.283,0.282,0.283,0.296,0.301,0.304,0.31,0.291,0.298,0.333,0.342,0.351,0.358,0.359,0.346,0.341,0.351,0.358,0.354,0.381,0.407,0.386,0.381,0.398,0.381,0.372,0.373,0.394,0.398,0.411,0.428,0.448,0.465,0.471,0.456,0.454,0.465,0.482,0.501,0.511,0.533,0.536,0.538,0.543,0.534,0.533,0.556,0.572,0.58,0.598,0.625,0.636,0.642,0.656,0.657,0.653,0.649,0.64,0.64,0.637,0.636,0.632],"content_fraction":0.061,"content_count":27,"regions":[[1,14],[432,444]]},"prediction-disorder-dis465":{"regions":[[1,12],[52,56],[101,101],[438,439],[441,444]],"content_count":24,"content_fraction":0.054},"prediction-disorder-disHL":{"regions":[[1,7],[9,16],[47,60],[64,65],[67,68],[82,90],[93,93],[107,107],[126,139],[153,166],[228,233],[348,357],[389,405],[427,436],[439,440],[442,444]],"content_count":120,"content_fraction":0.27},"prediction-disorder-espN":{"regions":[[1,15],[51,57],[260,262]],"content_count":25,"content_fraction":0.056},"prediction-disorder-espX":{"regions":[[1,17],[53,54],[439,444]],"content_count":25,"content_fraction":0.056},"prediction-disorder-glo":{"regions":[[3,4],[7,7],[9,10],[87,98],[129,136],[259,271],[435,435],[438,438],[442,442]],"content_count":41,"content_fraction":0.092},"prediction-disorder-iupl":{"regions":[[1,10],[91,93]],"content_count":13,"content_fraction":0.029},"prediction-disorder-iups":{"regions":[[1,10],[440,444]],"content_count":15,"content_fraction":0.034},"prediction-disorder-priority":{"regions":[[1,14],[432,444]],"content_fraction":0.061,"content_count":27},"prediction-disorder-th_50":{"regions":[[1,12],[53,54],[442,444]],"content_count":17,"content_fraction":0.038},"prediction-lip-alphafold":{"scores":[0.729,0.725,0.725,0.723,0.722,0.717,0.721,0.71,0.695,0.721,0.718,0.751,0.78,0.816,0.574,0.576,0.553,0.516,0.494,0.481,0.461,0.424,0.4,0.384,0.352,0.327,0.329,0.333,0.337,0.351,0.355,0.374,0.386,0.398,0.414,0.431,0.436,0.432,0.411,0.415,0.376,0.399,0.425,0.434,0.445,0.449,0.451,0.459,0.447,0.446,0.451,0.422,0.396,0.384,0.361,0.358,0.335,0.346,0.351,0.341,0.325,0.335,0.33,0.317,0.304,0.331,0.309,0.28,0.279,0.269,0.27,0.27,0.27,0.271,0.279,0.289,0.302,0.316,0.332,0.321,0.334,0.348,0.342,0.327,0.358,0.397,0.4,0.423,0.457,0.452,0.46,0.471,0.474,0.454,0.45,0.43,0.428,0.422,0.438,0.431,0.43,0.425,0.41,0.402,0.43,0.417,0.4,0.396,0.4,0.368,0.341,0.338,0.306,0.278,0.292,0.276,0.254,0.267,0.294,0.303,0.303,0.316,0.302,0.292,0.325,0.324,0.346,0.372,0.369,0.353,0.385,0.392,0.38,0.383,0.393,0.381,0.365,0.377,0.376,0.359,0.352,0.371,0.359,0.346,0.33,0.358,0.366,0.394,0.381,0.358,0.373,0.345,0.353,0.354,0.356,0.361,0.375,0.378,0.369,0.385,0.386,0.384,0.366,0.367,0.366,0.357,0.349,0.355,0.339,0.336,0.33,0.314,0.287,0.309,0.321,0.299,0.297,0.262,0.28,0.27,0.234,0.227,0.244,0.233,0.204,0.225,0.237,0.236,0.241,0.269,0.29,0.277,0.273,0.273,0.277,0.27,0.29,0.303,0.28,0.256,0.256,0.257,0.265,0.256,0.252,0.252,0.253,0.235,0.235,0.248,0.259,0.259,0.262,0.266,0.237,0.218,0.216,0.212,0.213,0.198,0.183,0.159,0.168,0.169,0.176,0.181,0.183,0.177,0.169,0.169,0.17,0.154,0.151,0.151,0.137,0.112,0.102,0.1,0.083,0.083,0.078,0.078,0.078,0.078,0.077,0.079,0.09,0.094,0.108,0.107,0.114,0.13,0.138,0.144,0.145,0.154,0.154,0.154,0.154,0.158,0.15,0.148,0.148,0.147,0.148,0.148,0.147,0.146,0.146,0.144,0.144,0.154,0.137,0.122,0.115,0.111,0.093,0.084,0.073,0.08,0.07,0.07,0.075,0.076,0.071,0.069,0.071,0.071,0.089,0.103,0.129,0.133,0.133,0.155,0.165,0.16,0.145,0.138,0.138,0.14,0.133,0.133,0.133,0.131,0.128,0.132,0.132,0.127,0.127,0.145,0.151,0.189,0.217,0.223,0.224,0.205,0.202,0.201,0.18,0.17,0.173,0.167,0.165,0.167,0.173,0.169,0.19,0.193,0.193,0.21,0.218,0.219,0.231,0.246,0.263,0.291,0.257,0.257,0.249,0.253,0.275,0.276,0.289,0.289,0.312,0.332,0.332,0.344,0.371,0.372,0.397,0.388,0.392,0.428,0.438,0.448,0.465,0.455,0.463,0.43,0.396,0.39,0.368,0.354,0.356,0.343,0.345,0.347,0.355,0.331,0.309,0.331,0.331,0.302,0.306,0.299,0.288,0.286,0.278,0.27,0.252,0.273,0.283,0.282,0.283,0.296,0.301,0.304,0.31,0.291,0.298,0.333,0.342,0.351,0.358,0.359,0.346,0.341,0.351,0.358,0.354,0.381,0.407,0.386,0.381,0.398,0.381,0.372,0.373,0.394,0.398,0.411,0.428,0.448,0.465,0.471,0.456,0.454,0.465,0.482,0.501,0.511,0.533,0.536,0.538,0.543,0.534,0.533,0.556,0.572,0.58,0.975,0.975,0.978,0.975,0.971,0.974,0.972,0.956,0.944,0.918,0.911,0.894,0.836],"content_fraction":0.034,"content_count":15,"regions":[[432,444]]},"prediction-lip-anchor":{"regions":[[34,35]],"content_count":2,"content_fraction":0.005},"prediction-lip-priority":{"regions":[[34,35],[432,444]],"content_fraction":0.034,"content_count":15},"prediction-plddt-alphafold":{"scores":[0.352,0.345,0.343,0.339,0.337,0.325,0.333,0.307,0.273,0.334,0.326,0.405,0.476,0.56,0.622,0.726,0.772,0.81,0.805,0.858,0.818,0.86,0.84,0.83,0.777,0.746,0.814,0.825,0.844,0.861,0.881,0.884,0.879,0.896,0.908,0.907,0.911,0.914,0.898,0.906,0.889,0.875,0.892,0.868,0.882,0.825,0.805,0.865,0.819,0.838,0.78,0.74,0.741,0.678,0.672,0.699,0.724,0.774,0.807,0.808,0.845,0.868,0.825,0.882,0.825,0.859,0.841,0.852,0.811,0.742,0.776,0.843,0.839,0.822,0.852,0.877,0.846,0.833,0.857,0.856,0.81,0.786,0.72,0.78,0.748,0.625,0.595,0.693,0.656,0.64,0.646,0.54,0.573,0.459,0.452,0.363,0.335,0.332,0.363,0.332,0.432,0.49,0.503,0.689,0.784,0.838,0.866,0.925,0.937,0.94,0.949,0.957,0.945,0.929,0.928,0.906,0.845,0.813,0.752,0.766,0.771,0.705,0.64,0.651,0.631,0.652,0.676,0.73,0.76,0.801,0.8,0.828,0.864,0.877,0.879,0.876,0.892,0.931,0.939,0.948,0.944,0.92,0.943,0.953,0.932,0.924,0.952,0.954,0.919,0.926,0.943,0.936,0.902,0.926,0.95,0.944,0.922,0.931,0.958,0.969,0.974,0.95,0.967,0.971,0.973,0.982,0.98,0.981,0.979,0.985,0.986,0.985,0.983,0.985,0.985,0.984,0.982,0.984,0.983,0.981,0.981,0.979,0.981,0.981,0.984,0.976,0.966,0.983,0.985,0.982,0.98,0.983,0.986,0.984,0.983,0.986,0.983,0.981,0.985,0.985,0.978,0.978,0.979,0.98,0.967,0.98,0.98,0.979,0.981,0.983,0.984,0.981,0.982,0.983,0.979,0.982,0.986,0.984,0.983,0.986,0.988,0.978,0.977,0.979,0.983,0.978,0.984,0.981,0.982,0.975,0.971,0.95,0.903,0.879,0.833,0.876,0.879,0.917,0.935,0.92,0.95,0.97,0.963,0.977,0.982,0.978,0.981,0.981,0.984,0.983,0.972,0.972,0.958,0.961,0.959,0.966,0.959,0.963,0.963,0.951,0.933,0.943,0.935,0.877,0.855,0.847,0.872,0.918,0.955,0.969,0.976,0.97,0.978,0.984,0.982,0.98,0.985,0.987,0.986,0.985,0.987,0.984,0.983,0.978,0.963,0.98,0.98,0.964,0.972,0.978,0.974,0.959,0.972,0.973,0.968,0.961,0.96,0.948,0.905,0.922,0.897,0.863,0.898,0.936,0.936,0.938,0.964,0.972,0.958,0.97,0.979,0.978,0.972,0.976,0.976,0.979,0.971,0.975,0.976,0.982,0.974,0.959,0.954,0.937,0.924,0.951,0.968,0.978,0.985,0.981,0.98,0.978,0.957,0.97,0.98,0.965,0.951,0.953,0.944,0.954,0.964,0.96,0.958,0.963,0.947,0.937,0.907,0.926,0.945,0.967,0.973,0.972,0.976,0.979,0.976,0.97,0.952,0.952,0.967,0.944,0.95,0.965,0.932,0.908,0.891,0.807,0.812,0.869,0.926,0.941,0.934,0.968,0.977,0.98,0.98,0.97,0.955,0.937,0.938,0.943,0.95,0.954,0.95,0.958,0.965,0.961,0.937,0.949,0.948,0.926,0.913,0.913,0.903,0.829,0.858,0.853,0.91,0.915,0.94,0.938,0.962,0.946,0.933,0.918,0.94,0.954,0.965,0.963,0.936,0.945,0.928,0.904,0.903,0.905,0.92,0.91,0.927,0.928,0.903,0.909,0.919,0.909,0.871,0.908,0.93,0.888,0.901,0.94,0.942,0.931,0.94,0.941,0.941,0.947,0.94,0.93,0.937,0.933,0.895,0.865,0.804,0.789,0.747,0.607],"content_fraction":0.903,"content_count":401,"regions":[[16,53],[57,85],[105,122],[128,443]]}}